Deals on vacations and trips to Mayo River

Save when you book Mayo River package deals

Choose two or more items and save on your trip:

Mayo River flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.
Quality Inn And Suites

Quality Inn And Suites

2.5 out of 5
Price was $349, price is now $296 per person
$296
per person
Feb 6 - Feb 9
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greensboro (GSO)
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
O.Henry Hotel

O.Henry Hotel

4 out of 5
Price was $559, price is now $438 per person
$438
per person
Feb 7 - Feb 9
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greensboro (GSO)
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free valet parking. Enjoy the seasonal outdoor pool and perks like free self parking.
The Shaffner Inn

The Shaffner Inn

3 out of 5
Price was $510, price is now $425 per person
$425
per person
Feb 6 - Feb 9
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greensboro (GSO)
A restaurant and a bar/lounge are featured at this hotel. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. A garden is also provided.
OYO Inn Kernersville

OYO Inn Kernersville

2.5 out of 5
Price was $359, price is now $302 per person
$302
per person
Feb 6 - Feb 9
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greensboro (GSO)
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock assistance.
OYO Hotel Greensboro East I 40

OYO Hotel Greensboro East I 40

2 out of 5
Price was $354, price is now $299 per person
$299
per person
Feb 6 - Feb 9
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Greensboro (GSO)
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Business travelers can take advantage of the express check-out. There's a fireplace in the lobby and multilingual staff can provide around-the-clock assistance.

Top Mayo River hotels deals

The Lodge at Primland, Auberge Collection

The Lodge at Primland, Auberge Collection

5 out of 5
2000 Busted Rock Rd Meadows Of Dan VA
$472 nightly
The price is $526 total per night
$526 total
Jan 15 - Jan 16, 2026
Total with taxes and fees
A full-service spa, 4 restaurants, and an indoor pool are all featured at this smoke-free lodge. Enjoy the 24-hour gym and perks like free valet parking and free WiFi. You'll appreciate the hot tub, bar/lounge, and concierge services.
Pool
Hot Tub
Baymont by Wyndham Eden

Baymont by Wyndham Eden

2.5 out of 5
716 Linden Dr Eden NC
Free Cancellation
Reserve now, pay when you stay
$77 nightly
The price is $86 total per night
$86 total
Dec 28 - Dec 29
Total with taxes and fees
This motel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like continental breakfast and free self parking.
Pool
Breakfast included
Comfort Inn Martinsville

Comfort Inn Martinsville

3 out of 5
378 Commonwealth Blvd W Martinsville VA
Free Cancellation
Reserve now, pay when you stay
$98 nightly
The price is $110 total per night
$110 total
Dec 25 - Dec 26
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the 24-hour business center and Internet in public areas. There's a gym on site, and a 24-hour front desk and express check-out are also provided.
Breakfast included
Parking included
Hampton Inn Martinsville

Hampton Inn Martinsville

2.5 out of 5
50 Hampton Dr Martinsville VA
Free Cancellation
Reserve now, pay when you stay
$142 nightly
The price is $158 total per night
$158 total
Jan 18 - Jan 19, 2026
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
Pool
Breakfast included
Hotel Floyd

Hotel Floyd

2 out of 5
300 Rick Lewis Way Floyd VA
Free Cancellation
Reserve now, pay when you stay
$110 nightly
The price is $121 total per night
$121 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Business travelers can take advantage of the business center. A restaurant, a 24-hour front desk, and free newspapers are also provided.
Parking included
Free WiFi
Econo Lodge Martinsville

Econo Lodge Martinsville

2 out of 5
1755 Virginia Ave Martinsville VA
Free Cancellation
Reserve now, pay when you stay
$61 nightly
The price is $67 total per night
$67 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This motel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self parking, a picnic area, and express check-in are also offered.
Pool
Pet friendly
Don't see what you're looking for?
See all available properties in Mayo River
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

The Reynolds Homestead, built in 1943 is in a beautiful foothill setting. Hardin Reynolds and his wife produced 16 children here, the most famous being RJ Reynolds who migrated to Winston Salem, NC to start the tobacco empire of the same name. The catalpa tree in the foreground still remains from the earliest days of the homestead.

Reynolds Homestead

You can study the exhibits at Reynolds Homestead, a museum with a story of its own, during your travels to Patrick Springs. Amble around the area's forest or visit its spas.

Reynolds Homestead

Frequently asked questions

How much are vacation packages to Mayo River?
Travelocity provides flight and hotel vacation packages starting at an incredible $296. With these kinds of savings, you'll be exploring all of Mayo River in the blink of an eye.
Where can I get the best vacation package deals for Mayo River?
You'll find an amazing range of Mayo River package deals on Travelocity. With as many as 400 air carriers and 1,000,000 worldwide properties, piecing together your ultimate getaway will be easy.
Why should I purchase my Mayo River vacation bundle with Travelocity?
With our Price Match Guarantee, we'll match any cheaper price you can find. Add to that our 24/7 support and exceptional service and the vacation of your dreams is well within reach.
Will I save money on my Mayo River car rental if I combine it with a hotel or flight?
Bundling your car, hotel and flight into a Mayo River vacation package is a surefire way to score an amazing deal. Plus, having your own set of wheels gives you freedom to find your way to all those amazing sights you're hoping to explore. Situated 75 mi from Mayo River, North Carolina Zoo is one place that should have a place on your itinerary. Fasten your seat belt and make a day trip of it.
Which airport is best for Mayo River?
Piedmont Triad Intl. Airport (GSO) is where many vacationers land. You'll find it around 40 mi south from inner Mayo River. Alternatively, check out the fares to Roanoke Regional Airport (ROA), which is 45 mi away from central Mayo River.

Photos of local treasures

Browse Mayo River vacation photos for more inspiration

Photo by Ed Mayfield
Photo by Ed Mayfield
Photo by Ed Mayfield
Photo by Ed Mayfield

Explore More Ways to Travel with Travelocity